The GLUT4 Glucose Transporter

Immunolocalization of glucose transporter GLUT4 within human skeletal muscle.

To investigate the cellular and subcellular distribution of glucose transporters in skeletal muscle, the glucose transporter isoform GLUT4 was localized in human muscle by electron microscopy via immunogold labeling with monoclonal (1F8) or COOH-terminal peptide polyclonal (ECU4) antibody and in isolated rat membranes by Western blot. There was no labeling of GLUT4 in endothelial cells of the c...

TUG cleavage regulates GLUT4 translocation Endoproteolytic cleavage of TUG regulates GLUT4 glucose transporter translocation*

Jonathan S. Bogan, Bradley R. Rubin, Chenfei Yu, Michael G. Löffler, Charisse M. Orme, Jonathan P. Belman, Leah J. McNally, Mingming Hao, and James A. Cresswell From the Section of Endocrinology and Metabolism, Department of Internal Medicine, and Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520-8020 Running head: TUG cleavage regulates GLUT4 translocation Add...

Structural and Functional Evolution of Glucose Transporter 4 (GLUT4): A Look at GLUT4 in Fish

Phosphorylation of the adipose/muscle-type glucose transporter (GLUT4) and its relationship to glucose transport activity.

The effects of protein phosphorylation and dephosphorylation on glucose transport activity reconstituted from adipocyte membrane fractions and its relationship to the phosphorylation state of the adipose/muscle-type glucose transporter (GLUT4) were studied. In vitro phosphorylation of membranes in the presence of ATP and protein kinase A produced a stimulation of the reconstituted glucose trans...

expression of glucose transporter 4 (glut4) is increased by cinnamaldehyde in c2c12 mouse muscle cells

background: in diabetes mellitus because of the absence or insufficient sensitivity to insulin, glucose transporter protein in cell membrane, glucose transporter 4, is decreased. glut4 is the major glucose transporter in skeletal muscle and adipose tissue, which is under control of insulin. it remains, however, unclear whether cinnamaldehyde plays a regulatory role(s) or not. objectives: the ob...